Endocrine Abstracts

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

Objectives: Hypogonadism is associated with a higher risk of atherosclerosis and cardiovascular disease, but the mechanisms underlying this association are not yet fully understood. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. We aimed to determine serum PON1 activities, an established lipid antioxidant, MDA levels which are end products of lipid peroxidation induced by ROS and thiol groups as an antioxidant fo...

Objective: GH deficiency is associated with an increased cardiovascular mortality. Increased oxidative stress has been associated with development of cardiovascular and cerebrovascular diseases. In the present study, we aimed to determine i) serum PON1 activities, an established lipid antioxidant, ii) MDA levels which are end products of lipid peroxidation induced by ROS and iii) thiol groups as an antioxidant for evaluating oxidative stress in patients with GHD before and aft...